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These prostanoids enhance myometrial contractility and vasoconstriction, resulting in ischemia and pain sensitization (Xie et al., 2020
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Heavy drinking depletes hepatic glutathione by 5080% within hours, creating a bottleneck where acetaldehyde accumulates faster than ALDH2 can clear it
Immune cytokine signatures of PASC patients reflect an ongoing chronic inflammation and angiogenesis with elevated plasma levels of IL-17a, stem cell factor, IL-12p70, IL-1, macrophage inflammatory protein-1 (MIP-1), brain-derived neurotrophic factor (BDNF), and VEGF 223 Also, among other immune mediators, reduced levels of cortisol strongly correlate with pulmonary-PASC symptoms 224
Metabolome changes in lupus PBL were most prominently impacted by the pentose phosphate pathway (PPP)
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